Fucose Binding Motifs on Mucin Core Glycopeptides Impact Bacterial Lectin Recognition

O-fucosylated glycan epitopes of membrane-bound mucin glycoproteins are key ligands many bacterial lectins. In their Research Article (e202302437), Ulrika Westerlind and co-workers describe the synthesis fucosylated glycopeptides using a chemoenzymatic approach. Starting from simple building blocks, Fmoc-protected glycosylated amino acids were prepared incorporated into peptides enzymatically diversified. Bacteria lectin interactions then elucidated on glycopeptide microarrays.